The default 'use' interaction key is 'F'. However if you change it to something other than F, you won't be able to pick up anything or use doors. The game is still prompting the player to press 'F' when attempting to interact with doors/dropped items even though you changed it.
I came across this bug when I changed my 'Use' key bind to 'E' and set my Fire Select Switch key to 'F'. I would approach a door, the game UI would prompt 'F' to open. However that's my fire select key, so it would only change fire select and not open the door.