I was thinking that New game + mode would be perfect for this game.
For example, if player chooses occupation with spot hidden skill,
in new game + mode, player could see some things which he wasn't able to in normal mode.
In NG+ he would have higher number threshold of some skill/ability which would trigger new events.
Maybe a bits of lore or some valuable items he couldn't spot in main game.
For example, if player maintains high insanity in the main game, in NG+ mode player will see more creatures. High insanity could drain his mind so he would need to solve some puzzles differently than in the main game
or having high insanity would give additional challenges/features.