I had a similar problem when I wanted to click a fleet, after the game failed to set itself to my resolution of 5040x1050 it tries to default and bypass your native monitor setting, it wanted to force me onto 1680x1050. This results in The game rescaling the screen and area and consequently some of the screen may become inaccessible, check your monitor and see if Tindalos supports your resolution. They have made a statement here in another thread that they 'will not be supporting' certain widescreen resolutions. Bad idea and this MAY be the reason for your problem. Lazy developing Tindalos.