Game has been running fine for over 400 hours. During my league match last night I had a crash. It continued to crash on the loading screen for the game until I timed out and was given a concede.

Loading a replay crashes the game in loading [sometimes] and I was able to load a friendly match with my wife's computer, but that crashed unexpectedly on turn 4.

I have no idea what might be causing this as it is the first time I've ever had trouble with the game. I have re-validated the game files and they were fine. My video drivers are up to date.

i7-7700 @ 3.60 GHz
GTX 1070