Irina Beckett Missing + 2 Security Guards

Irina Beckett is missing for me on the stairs where the wiki tells me I should find her, and the two guards that should be at the bottom near the train tracks are missing as well, not sure if anything could be done but I wanted to progress the Irina quest line.

Did you get her a staff from one of the security members? If you don't interact with her the first time she won't appear anymore, many of the npcs you help function like this.